Cultivation conditions and biochemical characterization of the proteolytic enzymes with fibrinolytic action obtained from mushrooms in the last ten years

Fibrinolytic enzymes are proteases that capable of degrading the fibrin mesh present in blood clots and can be obtained through fungal extracts. Thus, objective this paper was to seek out compare all information regarding production biochemical characterization fibrinolytic mushroom species published papers last ten years. The research carried eight national international electronic databases using terms: “fungal enzymes”, “fibrinolytic Proteases”, “thrombosis” “mushrooms”. results were analyzed according each step. In first stage, titles abstracts independently; second read those did not meet inclusion criteria excluded. Then, remaining reviewed data tabulated compared. As a result, it found with action from mushrooms period research: P. sajor-cashew, ferulae, ostreatus, L. shimeji, A. polytricha, H. erinaceum, C. comatus militaris. identified as protease SPPs, metalloproteases, serine metalloproteases. methods used evaluate activity plate method and/or formation artificial thrombus thrombin fibrinogen. molecular mass these ranged ~18 66 kDa and, for extracts, pH 4.0 9.5 optimum temperature 25 70 ºC. Via review, observed few articles on subject question, which made necessary carry more studies discover biotechnological properties define their applications most diverse sectors industries, only commercial mushrooms, but also native species.